Advancements of the 21st century and Their Implications on Medical Research and Diagnosis
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DOI:
https://doi.org/10.31039/plic.2024.11.254Keywords:
Genetics, Imaging, Medicine, Ethics, AI and RobotsAbstract
Throughout the 20th century, new research and new demands have led to an increased amount of technology used in medicine. These methods have led to early detection, better context of conditions, increased efficiency, and brighter prospects for the future of medical diagnosis. However, the increasing use of AI and genetics in medicine has called for checks and further clinical trials to determine how ethical these practices might be. The debate surrounding the integration of Artificial Intelligence has created further controversy—that is, what technologies should be used and what technologies should not be used. To determine a solution, certain factors should be considered including the comfort of patients during treatments including advanced technology, the risk factor of integrating AI into procedures, and the efficiency of technology compared to traditional medical practices. For example, imaging technologies such as X-ray and sonography are found to be more comfortable for patients due to their long-standing familiarity, yet their precision and accuracy fall short in comparison to advanced Imaging technologies such as CT, MRI, and PET scans. There has also been discussion of the use of genetic testing such as chromosomal microarrays. Advances in genetic testing have led to the ability to detect conditions in embryos which can be beneficial, but the manipulation of the embryos could raise ethical concerns. Past ethical grey areas, there have been amazing prospects for the future of medicine and these innovations, such as the use of non-invasive testing which is an emerging alternative to traditional surgical methods. Through extensive literary research, this paper considers the multiple aspects that should contribute to deciding to implement technological advancements brought in the 21st Century. By investigating previous integrations of innovations within medicine, this research could envision a risk-free and more ethical approach to advancing medicine with technology.
References
Anaclerio, F., Lucrezia Pilenzi, Dell’Elice, A., Ferrante, R., Grossi, S., Luca Maria Ferlito, Marinelli, C., Gildetti, S., Calabrese, G., Liborio Stuppia, & Antonucci, I. (2023). Clinical usefulness of NGS multi-gene panel testing in hereditary cancer analysis. Frontiers in Genetics, 14. https://doi.org/10.3389/fgene.2023.1060504
Angeli, D., Salvi, S., & Tedaldi, G. (2020). Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test? International Journal of Molecular Sciences, 21(3). https://doi.org/10.3390/ijms21031128
Arthur, C., Carlson, L.-M., Svoboda, J., Sandvik, U., Jylhä, C., Magnus Nordenskjöld, Holm, S., & Tham, E. (2024). Liquid biopsy guides successful molecular targeted therapy of an inoperable pediatric brainstem neoplasm. Npj Precision Oncology, 8(1). https://doi.org/10.1038/s41698-024-00535-8
Bradfield, B. (2023, November 17). What’s New in MRI Technology — 2024 Edition. Www.cassling.com. https://www.cassling.com/blog/whats-new-in-mri-technology-2024-edition
CDC. (2024). Tuberculosis Whole-Genome Sequencing. Tuberculosis (TB). https://www.cdc.gov/tb/php/genotyping/whole-genome-sequencing.html
Deo, N., & Anjankar, A. (2023). Artificial Intelligence With Robotics in Healthcare: A Narrative Review of Its Viability in India. Artificial Intelligence with Robotics in Healthcare: A Narrative Review of Its Viability in India, 15(5). https://doi.org/10.7759/cureus.39416
Dwamena, B. A., Sonnad, S. S., Angobaldo, J. O., & Wahl, R. L. (1999). Metastases from Non-Small Cell Lung Cancer: Mediastinal Staging in the 1990s—Meta-analytic Comparison Of PET and CT. Radiology, 213(2), 530–536. https://doi.org/10.1148/radiology.213.2.r99nv46530
Frost, A. (2015). Single gene sequencing — Knowledge Hub. GeNotes. https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/single-gene-sequencing/#:~:text=If%20the%20 patient
Ghosh, S., Dhobley, A., Avula, K. K., Joseph, S., Gavali, N., & Sinha, S. (2022). Role of Saliva as a Non-Invasive Diagnostic Method for Detection of COVID-19. Cureus. https://doi.org/10.7759/cureus.27471
Ghoshal, U. C. (2011). How to Interpret Hydrogen Breath Tests. Journal of Neurogastroenterology and Motility, 17(3), 312–317. https://doi.org/10.5056/jnm.2011.17.3.312
Greffier, J., Dabli, D., Hamard, A., Akessoul, P., Belaouni, A., Beregi, J.-P., & Frandon, J. (2021). Impact of dose reduction and the use of an advanced model-based iterative reconstruction algorithm on spectral performance of a dual-source CT system: A task-based image quality assessment. Diagnostic and Interventional Imaging, 102(7-8), 405–412. https://doi.org/10.1016/j.diii.2021.03.002
Hamzelou, J. (2023, March 10). More than 200 people have been treated with experimental CRISPR therapies. MIT Technology Review. https://www.technologyreview.com/2023/03/10/1069619/more-than-200-people-treated-with-experimental-crispr-therapies/
Henderson, H. (2021, March 3). CRISPR Clinical Trials: A 2021 Update. Innovative Genomics Institute (IGI). https://innovativegenomics.org/news/crispr-clinical-trials-2021/
Hiraki, T., Tetsushi Kamegawa, Matsuno, T., Sakurai, J., Yasuzo Kirita, Matsuura, R., Yamaguchi, T., Sasaki, T., Toshiharu Mitsuhashi, Toshiyuki Komaki, Yoshihisa Masaoka, Matsui, Y., Fujiwara, H., Iguchi, T., Hideo Gobara, & Kanazawa, S. (2017). Robotically Driven CT-guided Needle Insertion: Preliminary Results in Phantom and Animal Experiments. Radiology, 285(2), 454–461. https://doi.org/10.1148/radiol.2017162856
Jiang, Y., Edwards, A. V., & Newstead, G. M. (2021). Artificial Intelligence Applied to Breast MRI for Improved Diagnosis. Radiology, 298(1), 38–46. https://doi.org/10.1148/radiol.2020200292
Quintiens, J., & van Lenthe, G. H. (2024). Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints. Current osteoporosis reports, 22(4), 387–395. https://doi.org/10.1007/s11914-024-00876-0
Kreel, L. (1991). Medical imaging. Postgraduate Medical Journal, 67(786), 334–346. https://doi.org/10.1136/pgmj.67.786.334
Lee, M. J., Hueniken, K., Kuehne, N., Lu, L., Jiang, S. X., Id Said, B., McCartney, A., Gao, Y., Liang, M., Obuobi, T., Sorotsky, H., Eng, L., Brown, M. C., Xu, W., & Liu, G. (2020). Cancer Patient-Reported Preferences and Knowledge for Liquid Biopsies and Blood Biomarkers at a Comprehensive Cancer Center. Cancer Management and Research, Volume 12, 1163–1173. https://doi.org/10.2147/cmar.s235777
Loevner, L. A., Learned, K. O., Mohan, S., O’Malley, B. W., Scanlon, M. H., Rassekh, C. H., & Weinstein, G. S. (2013). Transoral robotic surgery in head and neck cancer: What radiologists need to know about the cutting edge. RadioGraphics, 33(6), 1759–1779. https://doi.org/10.1148/rg.336135518
Lynch, D. A., & Oh, A. S. (2020). High-Spatial-Resolution CT Offers New Opportunities for Discovery in the Lung. Radiology, 297(2), 472–473. https://doi.org/10.1148/radiol.2020203473
Medline Plus. (2021, July 28). What are whole exome sequencing and whole genome sequencing?: MedlinePlus Genetics. Medlineplus.gov. https://medlineplus.gov/genetics/understanding/testing/sequencing/
Merzenich, H., Krille, L., Hammer, G., Kaiser, M., Yamashita, S., & Zeeb, H. (2012). Paediatric CT scan usage and referrals of children to computed tomography in Germany-a cross-sectional survey of medical practice and awareness of radiation related health risks among physicians. BMC Health Services Research, 12(1). https://doi.org/10.1186/1472-6963-12-47
Muaddi, H., Hafid, M. E., Choi, W. J., Lillie, E., de Mestral, C., Nathens, A., Stukel, T. A., & Karanicolas, P. J. (2020). Clinical Outcomes of Robotic Surgery Compared to Conventional Surgical Approaches (Laparoscopic or Open). Annals of Surgery, 273(3), 467–473. https://doi.org/10.1097/sla.0000000000003915
OLD, J. L., DUSING, R. W., YAP, W., & DIRKS, J. (2005, January 1). Imaging for Suspected Appendicitis. AAFP. https://www.aafp.org/pubs/afp/issues/2005/0101/p71.pdf
Pétré, B., Paridans, M., Gillain, N., Husson, E., Donneau, A.-F., Dardenne, N., Breuer, C., Michel, F., Dandoy, M., Bureau, F., Gillet, L., Leclercq, D., & Guillaume, M. (2022). Acceptability of Community Saliva Testing in Controlling the COVID-19 Pandemic: Lessons Learned from Two Case Studies in Nursing Homes and Schools. Patient Preference and Adherence, Volume 16, 625–631. https://doi.org/10.2147/ppa.s349742
Reddy, U. M., Page, G. P., Saade, G. R., Silver, R. M., Thorsten, V. R., Parker, C. B., Pinar, H., Willinger, M., Stoll, B. J., Heim-Hall, J., Varner, M. W., Goldenberg, R. L., Bukowski, R., Wapner, R. J., Drews-Botsch, C. D., O’Brien, B. M., Dudley, D. J., & Levy, B. (2012). Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth. New England Journal of Medicine, 367(23), 2185–2193. https://doi.org/10.1056/nejmoa1201569
Rowe, S. P., & Pomper, M. G. (2021). Molecular imaging in oncology: Current impact and future directions. CA: A Cancer Journal for Clinicians, 72(4), 333–352. https://doi.org/10.3322/caac.21713
Saliva Testing for COVID-19 Quicker, Safer Than Nasal Swabs. (2022, March 21). ASM; American Society for Microbiology. https://asm.org/press-releases/2022/march-2022/saliva-testing-for-covid-19-quicker,-safer-than-na#:~:text=Washington%2C%20D.C.%20%E2%80%93%20 Genetic%20testing%20 of,the%20American%20Society%20 for%20 Microbiology.
Smolock, Amanda R., et al. “Robotically Assisted Sonic Therapy as a Noninvasive Nonthermal Ablation Modality: Proof of Concept in a Porcine Liver Model.” Radiology, vol. 287, no. 2, May 2018, pp. 485–493, https://doi.org/10.1148/radiol.2018171544.
Stein, R. (2023, December 25). Sickle cell patient’s journey leads to landmark approval of gene-editing treatment. NPR. https://www.npr.org/sections/health-shots/2023/12/25/1219342935/sickle-cell-patients-journey-leads-to-landmark-approval-of-gene-editing-treatmen
Tan, S., Allicock, O., Katamba, A., Carrington, C., Wyllie, A., & Armstrong-Hough, M. (2022). Saliva-based methods for SARS-CoV-2 testing in low- and middle-income countries. Bulletin of the World Health Organization, 100(12), 808–814. https://doi.org/10.2471/blt.22.288526
The Nobel Prize in Physiology or Medicine 1978. (n.d.). NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1978/summary/
The, B. (2022, August 30). Solving Oncology Cases With Chromosomal Microarrays. Behind the Bench; Thermo Fisher Scientific. https://www.thermofisher.com/blog/behindthebench/solving-oncology-cases-with-chromosomal-microarrays/#:~:text=CMA%20is%20a%20 powerful%20tool
What to expect. Stanford Health Care. (2017a, September 12). https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html#:~:text=A%20PET%20scan%20can%20be,being%20used%20in%20the%20 brain
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Copyright (c) 2024 Anna Browning, Leeann Bushmais, Ameena Rahman
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