The microbiota behind the mental health epidemic


Abstract views: 101

Authors

  • Alex Moss Louisiana State University- USA

DOI:

https://doi.org/10.31039/plic.2024.11.252

Keywords:

Microbiota, microbiota-gut-brain (MGB) axis, nervous system, vagus nerve, neurotransmitters

Abstract

Our microbiota plays a significant role in overall human health through communication with our brain, known as the MGB axis. The microbiota-gut-brain, or MGB axis, allows the microbiota and nervous system to communicate bidirectionally through the vagus nerve. This crucial transmission of vital information is upheld by the vagus nerve to sufficiently relay information regarding the regulation of the cholinergic anti-inflammatory pathway as well as upholding communication between the nucleus tractus solitarius and the gastrointestinal tract, both of which have been found connecting to correlations within mental illnesses such as depression, PTSD, schizophrenia, autism, and a plethora of other conditions. In cases of autism, researchers have found an increase in bacteria such as prevotellaceae and parabaderoids, while there was a decrease in Bifidobacterium and Collinsella compared to the control group. The interactions within the MBG axis responsible for psychiatric health are immense and still being explored. An example of such interconnectivity would be the production of neurotransmitters such as 90% of the serotonin in our body, crucial for regulating mood. This is accomplished by bifidobacterium infantis converting tryptophan into serotonin. Taking this new information into consideration the ramifications of the modern diet could be taken into consideration to explain the epidemic of poor mental health within modern generations. Specifically modern research entails that there is a rise in dysbiosis occurring as diversity and quantities of gut bacteria decrease due to the poor levels of nutrient-filled foods. A new approach to mental health treatment would consider a patient's microbiota and diet to assess what steps can be achieved to formulate a proper microbiota that produces adequate amounts of needed neurotransmitters such as serotonin, GABA, and dopamine that help combat many arising disorders.

References

Zhu, Sibo, et al. “The Progress of Gut Microbiome Research Related to Brain Disorders - Journal of Neuroinflammation.” SpringerLink, BioMed Central, 17 Jan. 2020, link.springer.com/article/10.1186/s12974-020-1705-z.

Malan-Muller, Stefanie, et al. “(PDF) the Gut Microbiome and Mental Health: Implications for Anxiety- and Trauma-Related Disorders.” The Gut Microbiome and Mental Health: Implications for Anxiety- and Trauma-Related Disorders, Journal of Integrative Biology, 1 Feb. 2018, www.researchgate.net/publication/318870864_The_Gut_Microbiome_and_Mental_Health_Implications_for_Anxiety-_and_Trauma-Related_Disorders.

Logan, Alan C, et al. “The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases.” Clinical Psychopharmacology and Neuroscience : The Official Scientific Journal of the Korean College of Neuropsychopharmacology, U.S. National Library of Medicine, 31 May 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4857870/.

Gerber, Georg K. “The Dynamic Microbiome.” FEBS Letters, No longer published by Elsevier, 28 Feb. 2014, www.sciencedirect.com/science/article/pii/S0014579314001574.

Peralta-Marzal, Lucia N., et al. “A Robust Microbiome Signature for Autism Spectrum Disorder across Different Studies Using Machine Learning.” Nature News, Nature Publishing Group, 8 Jan. 2024, www.nature.com/articles/s41598-023-50601-7#:~:text=Both%20genera%20belonging%20to%20Actinobacteria,cases%20when%20compared%20to%20controls.

Taniya, Masuma Afrin, et al. “Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation.” Frontiers in Cellular and Infection Microbiology, U.S. National Library of Medicine, 22 July 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC9355470/.

Terry, Natalie, and Kara Gross Margolis. “Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.” Handbook of Experimental Pharmacology, U.S. National Library of Medicine, 25 July 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5526216/.

Archie, Elizabeth A, and Jenny Tung. “Social Behavior and the Microbiome.” Current Opinion in Behavioral Sciences, Elsevier, 6 Aug. 2015, www.sciencedirect.com/science/article/pii/S2352154615001060.

Published

2024-09-06

How to Cite

Moss, A. (2024). The microbiota behind the mental health epidemic. Proceedings of London International Conferences, (11), abs1. https://doi.org/10.31039/plic.2024.11.252